Selected Publications

Bakhti-Suroosh A, Nesil T, Lynch WJ, Tamoxifen blocks the development of motivational features of an addiction-like phenotype in female rats., 2019; Special Edition, Frontiers in Behavioral Neuroscience: Sexual Behavior as a Model for the Study of Motivational Drive and Related Behaviors. 13: 253.  PMCID: PMC6856674

Abel JM, Nesil T, Bakhti-Suroosh A, Grant PA, Lynch WJ, Mechanisms underlying the efficacy of exercise as an intervention for cocaine relapse: a focus on mGlu5 in the dorsal medial prefrontal cortex., 2019; Psychopharmacology (Berl). 236(7) 2155-2171. PMCID: PMC6626681

Sanchez V, Bakhti-Suroosh A, Chen A, Brunzell DH, Erisir A, Lynch WJ, Exercise during abstinence normalizes ultrastructural synaptic plasticity associated with nicotine-seeking following extended access self-administration., 2019; European Journal of Neuroscience. 50(4) 2707-2721. PMCID: PMC6742551

Nesil T, Narmeen S, Bakhti-Suroosh A, Lynch WJ, Effect of menthol on nicotine intake and relapse vulnerability in a rat model of concurrent intravenous menthol/nicotine self-administration., 2019; Psychopharmacology (Berl). 236(4) 1219-1232. PMCID: PMC6536373

Lynch WJ, Tan L, Narmeen S, Beiter R, Brunzell DH, Exercise or saccharin during abstinence block estrus-induced increases in nicotine-seeking., 2019; Physiology & Behavior. 203 33-41. PMCID: PMC5927845

Lynch WJ, Robinson AM, Abel J, Smith MA, Exercise as a prevention for substance use disorder: a review of sex differences and neurobiological mechanisms., 2017; Current Addiction Reports. 4(4) 455-466. PMCID: PMC5802367

Lynch WJ, Abel J, Robinson AM, Smith MA, Exercise as a sex-specific treatment for substance use disorder., 2017; Current Addiction Reports. 4(4) 467-481. PMCID: PMC5796660

Beiter RM, Peterson AB, Abel J, Lynch WJExercise during early, but not late abstinence, attenuates subsequent relapse vulnerability in a rat model., 2016; Translational Psychiatry. 26 e792. PMCID: PMC4872415

Doyle SE, Ramôa C, Garber G, Newman J, Toor Z, Lynch WJ, A shift in the role of glutamatergic signaling in the nucleus accumbens core with the development of an addicted phenotype., 2014; Biological Psychiatry. 76(10) 810-5. PMCID: PMC4133320

Ramôa CP, Doyle SE, Lycas MD, Chernau AK, Lynch WJ, Diminished role of dopamine D1-receptor signaling with the development of an addicted phenotype in rats., 2014; Biological Psychiatry. 76(1) 8-14.  PMCID: PMC3976474

Peterson AB, Hivick DP, Lynch WJ, Dose-dependent effectiveness of wheel running to attenuate cocaine-seeking: impact of sex and estrous cycle in rats., 2014; Psychopharmacology. 231(13) 2661-70. PMID: 24464528

Peterson AB, Abel JM, Lynch WJ, Dose-dependent effects of wheel running on cocaine-seeking and prefrontal cortex Bdnf exon IV expression in rats., 2014; Psychopharmacology. 231(7) 1305-14. PMID: 24173624

Ramôa CP, Doyle SE, Naim DW, Lynch WJ, Estradiol as a mechanism for sex differences in the development of an addicted phenotype following extended access cocaine self-administration., 2013; Neuropsychopharmacology. 38(9) 1698-705. PMCID: PMC3717535

Doyle SE, Breslin FJ, Rieger JM, Beauglehole A, Lynch WJ, Time and sex-dependent effects of an adenosine A2A/A1 receptor antagonist on motivation to self-administer cocaine in rats., 2012; Pharmacology Biochemistry and Behavior. 102(2) 257-63. PMCID: PMC3383440

Lynch WJ, Bond C, Breslin FJ, Johnson BA, Severity of drinking as a predictor of efficacy of the combination of ondansetron and topiramate in rat models of ethanol consumption and relapse., 2011; Psychopharmacology. 217(1) 3-12. PMID: 21424693

Lynch WJ, Piehl KB, Acosta G, Peterson AB, Hemby SE, Aerobic exercise attenuates reinstatement of cocaine-seeking behavior and associated neuroadaptations in the prefrontal cortex., 2010; Biological psychiatry. 68(8) 774-7. PMID: 20692647 PMCID: PMC2949528

Abdolahi A, Acosta G, Breslin FJ, Hemby SE, Lynch WJ, Incubation of nicotine seeking is associated with enhanced protein kinase A-regulated signaling of dopamine- and cAMP-regulated phosphoprotein of 32 kDa in the insular cortex., 2010; The European journal of neuroscience. 31(4) 733-41. PMID: 20384816

Lynch WJ, Nicholson KL, Dance ME, Morgan RW, Foley PL, Animal models of substance abuse and addiction: implications for science, animal welfare, and society., 2010; Comparative medicine. 60(3) 177-88. PMID: 20579432 PMCID: PMC2890392

Lynch WJ, Sex and ovarian hormones influence vulnerability and motivation for nicotine during adolescence in rats., 2009; Pharmacology, biochemistry, and behavior. 94(1) 43-50. PMID: 19619575 PMCID: PMC2766849

Breslin FJ, Johnson BA, Lynch WJ, Effect of topiramate treatment on ethanol consumption in rats., 2009; Psychopharmacology. 207(4) 529-34. PMID: 19823810

Lynch WJ, Girgenti MJ, Breslin FJ, Newton SS, Taylor JR, Gene profiling the response to repeated cocaine self-administration in dorsal striatum: a focus on circadian genes., 2008; Brain research. 1213() 166-77. PMID: 18452895 | PMCID: PMC2494701

Lynch WJ, Acquisition and maintenance of cocaine self-administration in adolescent rats: effects of sex and gonadal hormones., 2007; Psychopharmacology. 197(2) 237-46. PMID: 18066534

Taylor JR, Lynch WJ, Sanchez H, Olausson P, Nestler EJ, Bibb JA, Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine., 2007; Proceedings of the National Academy of Sciences of the United States of America. 104(10) 4147-52. PMID: 17360491 | PMCID: PMC1820723

Lynch WJ, Kiraly DD, Caldarone BJ, Picciotto MR, Taylor JR, Effect of cocaine self-administration on striatal PKA-regulated signaling in male and female rats., 2006; Psychopharmacology. 191(2) 263-71. PMID: 17180335